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She is bubbly and her eyes sparkle as she talks about her dreams, and then she lights up like a Christmas tree just as we enter into the most crucial part of her story. Some 9, disabled and HIV positive persons in Coast want government to train health service providers on testing, treatment and care to offer quality services. Kenyans who are HIV-positive are likely to experience discrimination at their workplace due to their status, a tribunal has said.
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HIV Type 1 Transmission Networks Among Men Having Sex with Men and Heterosexuals in Kenya
Originally integrated within a community at a local tea plantation in Kericho, the MHRP Kenya program has developed expertise and infrastructure to support HIV vaccine, therapeutic and other infectious diseases research. The HIV research and care programs are mutually synergistic with long-term capacity building and sustainability. Ongoing studies include:.
The Kericho site has participated in studies focusing on HIV treatment and management of co-morbidities such as TB, fungal infections and Kaposi’s sarcoma. The focal location of operations is Nairobi at the Defense Forces Memorial Hospital, with services extended to 10 HIV comprehensive care centers and one community outreach clinic, located in Mtwonge, which serves surrounding civilian populations. The center offers a dynamic approach to behavior change and HIV prevention by combining recreational services with HIV counseling and testing.
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We performed a molecular phylogenetic study on HIV-1 polymerase sequences of men who have sex with men MSM and heterosexual patient samples in Kenya to characterize any observed HIV-1 transmission networks. HIV-1 polymerase sequences were obtained from samples in Nairobi and coastal Kenya from 84 MSM, other men, and women from to Using Bayesian phylogenetics, we tested whether sequences clustered by sexual orientation and geographic location.
In addition, we used trait diffusion analyses to identify significant epidemiological links and to quantify the number of transmissions between risk groups. However, a weak but significant link was evident when studying all subtypes together. GenBank comparison did not reveal other important transmission links. S ex between men has only recently been recognized as an important route of HIV-1 transmission in sub-Saharan Africa.
Several molecular phylogenetic studies have shown the potential of HIV-1 polymerase pol sequences to provide insight into HIV-1 transmission networks, revealing infections related by time, geographic area, and risk group. Sequences were selected from a cohort study among MSM and female sex workers FSW in coastal Kenya and MSM sex workers in Nairobi, and from female and male patients who participated in antiretroviral drug resistance monitoring studies in hospital-based clinics in the same geographic areas.
The route of infection of the hospital clinic comparison population was unknown, but was assumed to be heterosexual for women. To reveal any other transmission networks, a comparison of the sequences from MSM was made with all sequences available online at GenBank. From July , a prospective study of adults at high risk for HIV-1 acquisition in coastal Kenya began enrolling volunteers.
At each visit, detailed sexual behavior questionnaires were completed, and volunteers received free condoms and HIV counseling and testing. The estimated date of infection was defined as the midpoint between the last seronegative and first seropositive sample, or 14 days prior to the first p24 antigen-positive sample, or 10 days prior to the first RNA-positive sample, in the absence of a positive p24 antigen or antibody test.
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